Genetic examinations list

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Karyotyping in postnatal diagnosis

Karyotyping to determine numerical and structural chromosomal aberrations (deviations) in postnatal diagnosis.

Material:

Peripheral blood

Turnover Time:

8 weeks

STATIM

4 weeks

Predictive mutation testing – SPAST gene (SPG4) and/or REEP1 gene (SPG31)

Testing for familial AD variants of SPAST gene (SPG4) and REEP1 gene (SPG31) using the NGS method.

Material:

Peripheral blood, Buccal swab …
Peripheral blood, Buccal swab, Isolated DNA from blood, Cultured cells

Turnover Time:

6 weeks

STATIM

3 weeks

Predisposition to coeliac disease HLA-DQ2.5 (DQA1*05/DQB1*02), HLA-DQ2.2 (DQA1*02/DQB1*02), HLA-DQ8 (DQA1*03/DQB1*03:02)

Testing for predisposition to coeliac disease by real-time PCR to detect DQ2.5, DQ2.2 and DQ8 haplotypes.

Material:

Peripheral blood, Buccal swab …
Peripheral blood, Buccal swab, Isolated DNA from blood

Turnover Time:

3 weeks

STATIM

3 weeks

KIR (Killer-cell immunoglobulin-like receptor) haplotype evaluation

The KIR haplotype (A/B) determination method allows for the identification of the mother's genetic makeup in the region of KIR receptors. These receptors play a crucial role in the communication between the mother's immune system and the embryo during pregnancy, where they recognize HLA-C molecules on the embryo's surface. Analysis of the KIR haplotype can help reveal specific maternal genotypes that, in combination with the fetal HLA-C, may be associated with a higher risk of pregnancy complications.

Material:

Peripheral blood, Isolated DNA from blood

Turnover Time:

3 weeks

STATIM

2 weeks

Paternity/relatedness test

Determination of paternity or relatedness by analysis of 16 STR markers.

Material:

Peripheral blood, Buccal swab …
Peripheral blood, Buccal swab, Isolated DNA from blood, Isolated DNA from chorionic villi, Isolated DNA from amniotic fluid, Isolated DNA from cordocentesis, DNA isolated from the product of conception, Cultured cells

Turnover Time:

3 weeks

Pharmacogenetics – PGX test

Testing for congenital predispositions affecting drug metabolism by SNP array.

Material:

Peripheral blood, Isolated DNA from blood

Turnover Time:

4 weeks

STATIM

3 weeks