Microdeletion of Y chromosome – AZFa, AZFb, AZFc including SRY

Test covered by the reimbursement:
Peripheral blood, Isolated DNA from blood
Turnover time:
3 we
1 week


Peripheral blood | 1x 3 ml of whole blood in K3 EDTA tube
Storage after examination: week after the report is issued 2 – 8°C
Isolated DNA from blood | 10–100 ng/μL of isolated DNA from blood in a PCR tube of at least 15 μL.
Storage after examination: stored in a DNA archive without restriction 15°C

Quick test description:

Testing for microdeletions in the AZF (azoospermia factors) region of the Y chromosome (AZFa, AZFb, AZFc) by fragmentation analysis.

Test details:

Male infertility is in certain cases induced by the presence of microdeletions in the so-called AZF region (Yq11.3 localisation). Their estimated incidence is 1:4,000 live births, but their proportion significantly increases in the group of infertile men. The AZF region is divided into three sub-regions referred to as AZFa, AZFb, AZFc. Genes occurring in this section participate in the process of spermatogenesis and are essential for male reproduction.